Double strand breaks may be a missing link between entropy and aging

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Publikace nespadá pod Filozofickou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

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LENÁRT Peter BIENERTOVÁ VAŠKŮ Julie

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Mechanisms of Ageing and Development
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
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Doi http://dx.doi.org/10.1016/j.mad.2016.06.002
Obor Genetika a molekulární biologie
Klíčová slova Aging; Entropy; Double strand breaks; Chromatin; DNA damage
Přiložené soubory
Popis It has been previously suggested that an increase in entropy production leads to aging. However, the mechanisms linking increased entropy production in living mass to aging are currently unclear. Even though entropy cannot be easily associated with any specific molecular damage, the increase of entropy in structural mass may be connected with heat stress, which is known to generate double strand breaks. Double strand breaks, which are in turn known to play an important role in process of aging, are thus connected to both aging and an increase of entropy. In view of these associations, we propose a new model where the increase of entropy leads to the formation of double strand breaks, resulting in an aging phenotype. This not only offers a new perspective on aging research and facilitates experimental validation, but could also serve as a useful explanatory tool.
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