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Čeština

Project information
Using phosphodiesterases to therapeutical manipulation of bone and cartilage cells

Information

This project doesn't include Faculty of Arts. It includes Faculty of Medicine. Official project website can be found on muni.cz.
Project Identification
NU21-06-00512
Project Period
5/2021 - 12/2025
Investor / Pogramme / Project type
Ministry of Health of the CR
  • Programme NU (2020 - 2026)
  • Subprogram 1 - standard
MU Faculty or unit
Faculty of Medicine
Cooperating Organization
University Hospital Brno-Bohunice
  • Responsible person MUDr. Jan Hořák

The project investigates which types of PDE are produced in bone and joint tissues, and how both currently used and newly developed PDE inhibitors could be utilised for the therapeutic manipulation of bone and cartilage cells. The data obtained may ultimately help to improve the condition of patients with musculoskeletal disorders and contribute to the treatment of patients with congenital skeletal dysplasia.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No. 3 – Good health and well-being Sustainable Development Goal No. 4 – Quality education Sustainable Development Goal No. 5 – Gender equality Sustainable Development Goal No. 17 – Partnerships for the goals

Publications

Total number of publications: 7

2025

  • FGFR2 residence in primary cilia is necessary for epithelial cell signaling

    NITĂ Alexandru POOVAKULATHU ABRAHAM Sara ELREFAAY Eman FAFÍLEK Bohumil ČÍŽKOVÁ Eliška URSACHI Vlad-Constantin GUDERNOVÁ Iva KOUDELKA Adolf DUDEJA Pooja GREGOR Tomáš FEKETOVÁ Zuzana RICO LLANOS Gustavo Adolfo SVOZILOVÁ Kateřina ÇELIKER Canan CZYREK Aleksandra Anna BÁRTA Tomáš TRANTÍREK Lukáš WIEDLOCHA Antoni KREJČÍ Pavel BOSÁKOVÁ Michaela

    Peer-reviewed scientific article

    Journal of cell biology, year: 2025, volume: 224, edition: 7, DOI

  • Increased thermal stability of FGF10 leads to ectopic signaling during development

    CZYREK Aleksandra Anna BARAN Karolina HRUBÁ Eva HORACKOVA Aneta BOSÁKOVÁ Veronika CHUDZIAN Julia FAFÍLEK Bohumil LASKOVA Veronika STEPANKOVA Veronika BEDNÁŘ David KARL Kelly KASPAREK Petr BOSÁKOVÁ Michaela KILLINGER Michal SZOTKOWSKA Tereza PROCHAZKA Jan ZIEBA Jennifer T RICO LLANOS Gustavo FRIČ Jan HADZIC Stefan LOKU Edma WUJAK Magdalena SVOZILOVÁ Kateřina STROBLOVÁ Michaela SEDLACEK Radislav HRISTOVA Kalina KRAKOW Deborah KUBOVCIAK Jan DELATTRE Mathys BARTOSZEWSKI Rafal BUCHTOVÁ Marcela KROWARSCH Daniel CHALOUPKOVÁ Radka ZAKRZEWSKA Malgorzata KREJČÍ Pavel

    Peer-reviewed scientific article

    Cellular and molecular life sciences, year: 2025, volume: 82, edition: 1, DOI

  • Protein structure and interactions elucidated with in-cell NMR for different cell cycle phases and in 3D human tissue models

    RYNEŠ Jan IŠTVÁNKOVÁ Eva KRAFČÍKOVÁ Michaela LUCHINAT Enrico BARBIERI Letizia BANCI Lucia KAMARÝTOVÁ Kristýna LOJA Tomáš FAFÍLEK Bohumil RICO LLANOS Gustavo KREJČÍ Pavel MACUREK Libor TRANTÍRKOVÁ Silvie TRANTÍREK Lukáš

    Peer-reviewed scientific article

    Communications Biology, year: 2025, volume: 8, edition: 1, DOI

  • Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer

    ZLÍNSKÁ Vladimíra FEKETOVÁ Zuzana CZYREK Aleksandra Anna CHUDZIAN Julia ZIVKOVIC Martina Lenarcic URSACHI Vlad-Constantin DUDEJA Pooja FAFÍLEK Bohumil RYNEŠ Jan RICO LLANOS Gustavo KOUDELKA Adolf ROY Tanaya BIADUN Martyna RAŠKOVÁ Vendula SVOZILOVÁ Kateřina STROBLOVÁ Michaela KRZYSCIK Mateusz HRISTOVA Kalina KROWARSCH Daniel TRANTÍRKOVÁ Silvie ZAKRZEWSKA Malgorzata TRANTÍREK Lukáš KREJČÍ Pavel

    Peer-reviewed scientific article

    MOLECULAR THERAPY-NUCLEIC ACIDS, year: 2025, volume: 36, edition: 1, DOI

2024

2022

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