Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Cooperating Organization
-
Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 328
2021
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Trimethylacetic Anhydride-Based Derivatization Facilitates Quantification of Histone Marks at the MS1 Level
Molecular and Cellurar Proteomic, year: 2021, volume: 20, edition: JAN 01, DOI
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Unique electrochemical properties of polymer pencil graphite leads
Year: 2021, type: Conference abstract
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Upconversion-Linked Immunoassay for the Diagnosis of Honeybee Disease American Foulbrood
IEEE Journal of Selected Topics in Quantum Electronics, year: 2021, volume: 27, edition: 5, DOI
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Variety of size and form of GRM2 bacterial microcompartment particles
Protein Science, year: 2021, volume: 30, edition: 5, DOI
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Virion Structure and In Vitro Genome Release Mechanism of Dicistrovirus Kashmir Bee Virus
Journal of Virology, year: 2021, volume: 95, edition: 11, DOI
2020
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A Model of Aerobic and Anaerobic Metabolism of Hydrogen in the Extremophile Acidithiobacillus ferrooxidans
Frontiers in Microbiology, year: 2020, volume: 11, edition: November 2020, DOI
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A Photochemical/Thermal Switch Based on 4,4'-Bis(benzimidazolio)stilbene: Synthesis and Supramolecular Properties.
ChemPhysChem, year: 2020, volume: 21, edition: 18, DOI
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Activation of glycogenolysis and glycolysis in breast cancer stem cell models
Biochimica et Biophysica Acta - Molecular Basis of Disease, year: 2020, volume: 1866, edition: 10, DOI
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Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera
Bioorganic Chemistry, year: 2020, volume: 104, edition: NOV, DOI
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Bacterial Diversity in the Asphalt Concrete Lining of the Upper Water Reservoir of a Pumped-Storage Scheme
WATER, year: 2020, volume: 12, edition: 11, DOI