Nucleosomal TATA-switch: Competing orientations of TATA on the nucleosome

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Authors

HAPALA Jan TRIFONOV Eduard Nikolajevič

Year of publication 2013
Type Article in Periodical
Magazine / Source Gene
MU Faculty or unit

Central European Institute of Technology

Citation
Doi http://dx.doi.org/10.1016/j.gene.2013.06.004
Field Genetics and molecular biology
Keywords TATA box; Eukaryotic promoter; Nucleosome mapping; Rotational positioning; Chromatin and transcription
Description Transcription is known to be affected by the rotational setting of the transcription response elements within nucleosomes.Our results show that the nucleosome DNA sequence harboring the TATA box encodes alternative rotational positions for the same piece of DNA. This may serve for switching the gene activity on and off.
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