Sequence-dependent separation of trinucleotides by ion-interaction reversed-phase liquid chromatography A structure-retention study assisted by soft-modelling and molecular dynamics

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Authors

MIKULÁŠEK Kamil JAROŇ Kamil KULHÁNEK Petr BITTOVÁ Miroslava HAVLIŠ Jan

Year of publication 2016
Type Article in Periodical
Magazine / Source Journal of Chromatography A
MU Faculty or unit

Central European Institute of Technology

Citation
Web supplementary data
Doi http://dx.doi.org/10.1016/j.chroma.2016.09.060
Field Analytic chemistry
Keywords Sequence-dependent separation; Ion-interaction reversed-phase liquid chromatography; Trinucleotides; Oligonucleotide sequence isomers; QSRR; Molecular dynamics
Attached files
Description Ultrashort oligonucleotides show consistent sequence-dependent separation behaviour, described via soft-modelling and molecular dynamics. Important factors determining this phenomenon were identified to be solvent accessible surface areas and electrostatic work of molecule transfer from vacuum into solvent, representing physico-chemical properties of the studied molecules.
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