Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice

Warning

This publication doesn't include Faculty of Arts. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors

HOFER M. HOFEROVA Z. GRUZDEV A. DUŠEK Ladislav FALK M.

Year of publication 2018
Type Article in Periodical
Magazine / Source Physiological research
MU Faculty or unit

Faculty of Medicine

Citation
Keywords Cyclooxygenase-2; COX-2 knock-out mice; Ionizing radiation; Post-irradiation survival; Post-irradiation inflammation
Description We investigated and evaluated post-irradiation survival in cyclooxygenase-2-deficient (COX-2 KO) mice. Thirty-day survival following exposure of COX-2 KO mice to a lethal dose of 8.5 Gy of gamma-rays was observed to be statistically significantly lower in both males and females, as well as when the sexes were merged, in comparisons with their wild-type counterparts. These findings were related to the previous observations concerning the detrimental influence of the COX-2 genetic disruption on hematopoiesis in sublethally irradiated mice. Deteriorated postirradiation survival of COX-2 KO mice confirmed the previously anticipated conclusion regarding negative influence of the antiinflammatory action of COX-2 deficiency under the conditions of exposure of the animals to ionizing radiation.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.