Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice


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Year of publication 2018
Type Article in Periodical
Magazine / Source Physiological research
MU Faculty or unit

Faculty of Medicine

Keywords Cyclooxygenase-2; COX-2 knock-out mice; Ionizing radiation; Post-irradiation survival; Post-irradiation inflammation
Description We investigated and evaluated post-irradiation survival in cyclooxygenase-2-deficient (COX-2 KO) mice. Thirty-day survival following exposure of COX-2 KO mice to a lethal dose of 8.5 Gy of gamma-rays was observed to be statistically significantly lower in both males and females, as well as when the sexes were merged, in comparisons with their wild-type counterparts. These findings were related to the previous observations concerning the detrimental influence of the COX-2 genetic disruption on hematopoiesis in sublethally irradiated mice. Deteriorated postirradiation survival of COX-2 KO mice confirmed the previously anticipated conclusion regarding negative influence of the antiinflammatory action of COX-2 deficiency under the conditions of exposure of the animals to ionizing radiation.
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