Function of chromatin structure and dynamics in DNA damage, repair and misrepair: γ-rays andprotons in action

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Authors

JEŽKOVÁ L FALK Martin FALKOVÁ I DAVÍDKOVÁ M BAČÍKOVÁ A ŠTEFANČÍKOVÁ Lenka VACHELOVÁ J Michaelidesová A LUKÁŠOVÁ Emilie BOREYKO A KRASAVIN E KOZUBEK Stanislav

Year of publication 2014
Type Article in Periodical
Magazine / Source Applied Radiation and Isotopes
Citation
Doi http://dx.doi.org/10.1016/j.apradiso.2013.01.022
Description According to their physical characteristics, protons and ion beams promise a revolution in cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than experimental data on DNA repair. This especially holds for the spatio-temporal organization of repair processes in the context of higher-order chromatin structure-the problematics addressed in this work. The consequences for the mechanism of chromosomal translocations are compared for gamma rays and proton beams.
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