Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer

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Authors

ROZSYPALOVA Aneta ROSOVA Blanka FILIPOVA Alzbeta NIKOLOV Dimitar Hadzi CHLOUPKOVÁ Renata RICHTER Igor PROKS Jan ZACHOVAL Roman MATEJ Radoslav MELICHAR Bohuslav BUCHLER Tomas DVORAK Josef

Year of publication 2019
Type Article in Periodical
Magazine / Source Journal of BUON
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.ncbi.nlm.nih.gov/pubmed/31646820
Keywords clear cell renal cancer; primary cilia; CD8+tumor infiltrating lymphocytes; programmed cell death protein 1
Description Purpose: The aim of this study was to investigate the potential association and combined prognostic significance of the frequency of primary cilia (PC), programmed cell death protein-1 receptor (PD1) and CD8+ tumor infiltrating lymphocytes (TIL) in patients with clear cell renal cancer (ccRCC). Methods: The frequency of PC, PD1 expression and the frequency of intratumoral CD8+ TIL were evaluated in 104 ccRCC patients. Results: The median frequency of PC was 0.003. The expression of PD1+ cells were <5% in 52 patients, 5-25% in 34 patients and 26-50% in 13 patients and >50% in 5 patients. Intratumoral CD8+ TIL were evaluable in all patients: negative in 1 patient, <25% in 63, 26-50% in 29 and >50% in 11 patients. Overall survival (OS) according to the frequency of PC was significantly shorter in patients with higher frequency (>= 0.002) than in patients with lower frequency (<0.002) (p<0.001). Median OS was significantly shorter in patients with higher (25%) CD8+ TIL and higher (>25%) PD1+ expression than in patients with lower (<25%) expression (4.6 vs. 97. years, p=0.006 and 2.9 vs. 8.9 years, p=0.006, respectively). Conclusions: The present study provides the first data on the potential association and combined prognostic significance of frequency of PC, PD1+ cells and CD8+ TIL in patients with clear cell renal cancer.
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