Fluorine Labeling as a Versatile Tool for Probing Nucleic Acid Folding and Interactions by NMR Spectroscopy
| Authors | |
|---|---|
| Year of publication | 2022 |
| Type | Article in Periodical |
| Magazine / Source | ALDRICHIMICA ACTA |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.sigmaaldrich.com/CZ/en/collections/aldrichimica-acta |
| Keywords | F-19 NMR spectroscopy; F-19 probes; DNA; RNA; F-19-labeling approaches; nucleic acid folding; nucleic acid/small molecule interactions; nucleic acid/protein interactions; in vitro; in vivo |
| Description | This mini-review provides an overview of approaches to F-19-labeling of nucleic acids. A special attention is paid to applications of F-19-labeled nucleic acids to resolve their polymorphism and characterize their folding and interactions with ligands and proteins in vitro and in living cells by using NMR spectroscopy. |
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