Biology and pharmacological inhibition of homeodomain-interacting protein kinases

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Authors	ŠTEFEK Adam PARUCH Kamil
Year of publication	2025
Type	Article in Periodical
Magazine / Source	Frontiers in Chemical Biology
MU Faculty or unit	Faculty of Science
Citation
web	https://doi.org/10.3389/fchbi.2025.1441138
Doi	https://doi.org/10.3389/fchbi.2025.1441138
Keywords	HIPK; kinase; inhibitor; selectivity; neurology; cancer
Description	Homeodomain-interacting protein kinases (HIPKs) represent a relatively underexplored sub-family of serine/threonine protein kinases. However, the recently published studies point to the role of HIPKs in the developmental biology and etiology of pathological states, in particular cancer, and potential therapeutic applications of targeting this kinase family. This review summarizes the biology of HIPKs and their heretofore published small-molecule inhibitors.
Related projects:	Národní infrastruktura chemické biologie