Effect of chronic fluoxetine treatment on methamphetamine i.v. self-administration in rats

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Authors	NOVÁKOVÁ Jana ŠULCOVÁ Alexandra
Year of publication	2002
Type	Article in Periodical
Magazine / Source	Behavioural Pharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	fluoxetine; methamphetamine; "i.v. self-administration"; rats
Description	The present study was designed to investigate the influence of chronic treatment with fluoxetine on both the training and maintenance of i.v. methamphetamine self-administration. Our results indicate that 5-HT re-uptake inhibition by fluoxetine may suppress either reinforcing mechanisms or sensitization to methamphetamine eliciting drug-wanting behaviour.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems