Changes in Telomerase Activity, Expression and Splicing in Response to Differentiation of Normal and Carcinoma Colon Cells

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Authors	FAJKUS Jiří BORSKÝ Marek KUNICKÁ Zuzana KOVAŘÍKOVÁ Martina DVOŘÁKOVÁ Dana HOFMANOVÁ Jiřina KOZUBÍK Alois
Year of publication	2003
Type	Article in Periodical
Magazine / Source	Anticancer Research
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	telomerase regulation; human colon cells; butyrate; alternative splicing; flow cytometry
Description	Downregulation of telomerase activity and expression occurs in response to butyrate-induced differentiation in normal and carcinoma colon cells. Differential splicing of hTERT mRNA may be involved in faster loss of telomerase activity in normal cells with respect to malignant cells.
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