Influence of ligands of serotonin receptors on the drug-metabolizing processes in the isolated perfused rat liver.

Warning

This publication doesn't include Faculty of Arts. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	SLÍVA Jiří DOSTÁLEK Miroslav TOMANDL Josef HADAŠOVÁ Eva
Year of publication	2003
Type	Article in Proceedings
Conference	PROGRAMME AND ABSTRACTS of 5th NEUROCHEMISTRY WINTER CONFERENCE.
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	isolated liver; CYP450
Description	The effects of selective ligands of 5-HT3 and 5-HT1A/1B receptors, tropisetrone and RU 249, on N-acetylation and cytochrome P460-mediated metabolism in the isolated perfused rat liver were followed. The study has shown significant inhibition of acetylation, but a marked stimulation of CYP 2D1 activity after administration of both substances, with higher significance in RU 24969.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems