Comparative study on the influence of methamphetamine and enzyme inducers on the activity of drug-metabolizing enzymes in the rat liver microsomes

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Authors	MINAŘÍKOVÁ Veronika HADAŠOVÁ Eva SIEGMUND Werner MORITZ Klaus-Uwe SCHEUCH Eberhard
Year of publication	2005
Type	Article in Proceedings
Conference	Sborník abstrakt. 55. česko-slovenských farmakologických dnů, 31.8.-2.9. 2005, Hradec Králové
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	methamphetamine; metabolic enzymes; microsomes; rat
Description	In the present study there was studied the influence of methamphetamine on the activity of cytochromes P450 and N-acetyltransferase (NAT)in the rat liver microsomes in comparison with the effect of known enzyme inducers: phenobarbital, beta-naphtoflavone and dexamethazone. Methamphetamine significantly inhibited CYP2E1, but, on the other hand, it stimulated NAT. Other investigated enzymes were not significantly influenced.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.