Relevance of immunological variables in neuroborreliosis and multiple sclerosis
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Acta Neurologica Scandinavica |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | MRZ reaction;multiple sclerosis; neuroborreliosis; immunological variables |
| Description | The aims were to investigate the frequency of intrathecal synthesis of specific antibodies against measles (M), rubella(R),and varicella zoster (Z)viruses(MRZ reaction) as a diagnostic marker between multiple sclerosis (MS) and neuroborreliosis (NB)groups and to postulate the most typical cerebrospinal fluid (CSF) variables profile of these entities. Three cohorts of patients were investigated :MS (n=42),NB (n=27) and other neurological diseases (OND) (n=15).Measles, rubella varicella zoster and borrelia specific IgG antibodies were measured by ELISA , Qalb as a marker of blood -CSF barrier function and specific antibody indices (AI) were calculated according to relevant formulae. IgG oligoclonal bands (OB) were detected by isoelectric focusing and immunoenzymatic staining. Results : Eighty- eight percent of MS patients had positive MRZ reaction and 26.2% had positive anti -borrelia AI. Eighty -nine percent of NB patients had positive anti-borrelia AI and two patients had individually anti measles and rubella positive AI. -MS CSF variables profile included the presence of IgG OB in 81% ,elevated Qalb in 31% and normal cell count in 7. 4%. Conclusion -MRZ reaction was proved as statistically significant marker in differential diagnosis between MS and NB. Typical CSF variables profile of these two entities is highly supportive , escpecially when MRZ is included. |
| Related projects: |