Involvement of cannabinoid CB1 and CB2 receptor activity in the development of behavioural sensitization to methamphetamine effects in mice

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Authors	LANDA Leoš ŠLAIS Karel ŠULCOVÁ Alexandra
Year of publication	2006
Type	Article in Periodical
Magazine / Source	Neuroendocrinology Letters
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	methamphetamine; cannabinoids; behavioural sensitization; locomotion; mice
Description	Methamphetamine produced significant sensitization to its stimulatory effect on locomotion. Methanandamide pre-treatment elicited cross-sensitization to methamphetamine effect, whereas pre-treatment with JWH 015 did not. Combined pre-treatment with methamphetamine+AM 251 suppressed sensitization to methamphetamine.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.