The effects of posttranslational modifications on function of the Bcl-2 protein

• Authors: ZAHRADNÍČKOVÁ Eva; VAŇKOVÁ Jana; MACEČKOVÁ Vendula; ŠMARDA Jan
• Year of publication: 2006
• Type: Article in Periodical
• Magazine / Source: Chemické listy
• MU Faculty or unit: Faculty of Science
• Field: Genetics and molecular biology
• Keywords: Bcl-2; apoptosis; cell differentiation; phosphorylation
• Description: BM2 monoblasts overexpressing Bcl-2 exhibit low viability, condensed chromatin, nuclear fragmentation and DNA fragmentation. Our results suggest that the Bcl-2 protein undergoing post-translational modification by phosphorylation cannot interact with its protein partners thus loosing its capability to suppress apoptosis.

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