Stimulace prefrontálního kortexu a léčba negativních příznaků schizofrenie

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Title in English	Stimulation of Prefrontal Cortex and Therapy of Negative Symptoms of Schizophrenia
Authors	PŘIKRYL Radovan ČEŠKOVÁ Eva KUČEROVÁ Hana KAŠPÁREK Tomáš USTOHAL Libor PALČÍKOVÁ Ivana
Year of publication	2006
Type	Article in Periodical
Magazine / Source	Česká a Slovenská psychiatrie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Psychiatry, sexuology
Keywords	frontal cortex; treatment; negative symptoms; rTMS; schizophrenia; stimulation
Description	Negative symptoms are regarded as the most persistent and disabling component of schizophrenia. The possibility of influencing them by means of antipsychotics remains problematic. Repetitive transcranial magnetic simulation (rTMS) presents a new opportunity for influencing negative schizophrenic symptoms. A theoretical justification of the effect of rTMS on negative schizophrenic symptoms can be seen in the fact that high-frequency rTMS has an activating impact on cortex neurons. The negative correlation between activity of the frontal cortex and severity of negative symptoms has been proved repeatedly. Another important fact is that dopamine can be released in the mesolimbic and mesostriatal brain systems by high-frequency stimulation of the frontal cortex. There are hardly any consistent published data mapping the subject in clinical practice.
Related projects:	Ovlivnění negativních příznaků schizofrenie pomocí repetitivní transkraniální magnetické stimulace (rTMS) v podmínkách jednoduše slepé, randomizované studie The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.