Blood Pressure and Baroreflex Sensitivity after Anthracycline Chemotherapy in Childhood with Respect to Fatty Acid Metabolism

Warning

This publication doesn't include Faculty of Arts. It includes Faculty of Medicine. Official publication website can be found on muni.cz.
Authors

ZÁVODNÁ Eva HRSTKOVÁ Hana BALCÁRKOVÁ Pavla NOVÁKOVÁ Zuzana HONZÍKOVÁ Nataša FIŠER Bohumil

Year of publication 2005
Type Article in Periodical
Magazine / Source Scripta medica
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords Anthracycline; Blood pressure; Baroreflex sensitivity; Heart rate variability; Cholesterol
Description Late effects of caardiotoxic therapy on childhood cancer were studied. Body and circulation parameters were compared in 206 helathy controls, and 97 children and adolescents after antitumour treatment at the age of 11 - 21 years with respect to plasma lipid level. The subjects after antitumour therapy had increased parasympathetic and decreased sympathetic tonic activity together with decreased baroreflex sensitivity. The increase of inter-beat interval variability was neither the result of a primary increase of vasomotor activity nor an increase of baroreflex sensitivity response to changes in blood pressure. We can explain it by increasing parasympathetic control of the heart. The circulatory changes did not bear on obesity, but they were rather a specific effect of tumour disease and antitumou treatment.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.