Twenty-four hour profile of blood pressure in children, adolescents and young adults after anthracycline therapy

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Authors

ŠŤASTNÁ Jana HRSTKOVÁ Hana HONZÍKOVÁ Klára NOVÁKOVÁ Zuzana HONZÍKOVÁ Nataša FIŠER Bohumil ZÁVODNÁ Eva

Year of publication 2008
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description The aim of this study is the cosinor analysis (fit of the cosine curve with a period of 24 hours: MESOR, midline-estimating; AMPLITUDE of the sinusoidal curve; ACROPHASE, timing of period) of the 24-hour recordings of systolic (SBP) and diastolic blood pressure (DBP) in 45 adolescents and young adults after anticancer therapy with anthracyclines (A) in comparison with 64 healthy controls (Co). A significant correlation between age and MESOR of SBP or DBP was found in Co, but not in A. AMPLITUDE and ACROPHASE were age-independent. MESOR values of SBP and DBP were decreased in A group in the age group of 19-22 years in comparison with Co of the same age. In the age group of 19-22 years, ACROPHASE was shifted in A one hour earlier. Conclusion: The age-dependent increase of BP seen in Co between 11 and 22 years of age does not occur in A group. This finding is consistent with the long-lasting impairment of the sympathetic nervous system caused by anthracycline toxicity.
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