CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells

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Authors	ANDERSSON Therese SÖDERSTEN Erik DUCKWORTH K. Joshua CASCANTE Anna FRITZ Nicolas SACCHETTI Paola ČERVENKA Igor BRYJA Vítězslav HERMANSON Ola
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Journal of Biological Chemistry
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	Wnt signalling; CXXC5; neural stem cells
Description	In a screen designed to identify novel targets of BMP4 signaling in telencephalic neural stem cells, we found that the levels of the previously uncharacterized factor CXXC5 were reproducibly up-regulated after BMP4 stimulation. We demonstrate that CXXC5 can interact with the Wnt-signaling intermediate Dishevelled and attenuate Wnt signalling. We conclude that CXXC5 is a BMP4-induced inhibitor of Wnt signaling in neural progenitors.
Related projects:	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies