Paliperidon mediated modification of cortical inhibition

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Authors

PŘIKRYL Radovan USTOHAL Libor PŘIKRYLOVÁ KUČEROVÁ Hana ČEŠKOVÁ Eva

Year of publication 2009
Type Article in Periodical
Magazine / Source Neuroendocrinology Letters
MU Faculty or unit

Faculty of Medicine

Citation
Field Psychiatry, sexuology
Keywords cortical silent period; first episode; GABA; paliperidon; transcranial magnetic stimulation; schizophrenia
Description Transcranial magnetic stimulation is a neurophysiological method which enables direct quantitative in vivo assessment of cortical excitability and inhibition. The aim of the study was to assess the impact of paliperidone on the motor threshold and cortical silent period, in a drug-naive patient, with first episode schizophrenia using this technique. Paliperidone monotherapy caused a significant reduction of severity of schizophrenic symptomatology in the patient. At the same time, a significant prolongation of the cortical silent period, from 118.68 ms before to 185.13 ms after therapy, occurred. Because the cortical silent period is a function of GABAB receptors, we can assume that paliperidone may have the ability to enhance GABAB receptor-mediated neurotransmission.
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