Levels of nestin protein correlate with 1q21 gain and hyperdiploidy in multiple myeloma

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Authors

ŠVÁCHOVÁ Hana NĚMEC Pavel MIKULÁŠOVÁ Aneta BERÁNKOVÁ Kristina GREŠLIKOVÁ Henrieta KOVÁŘOVÁ Lucie HÁJEK Roman

Year of publication 2011
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Nestin is considered to be a suitable diagnostic and prognostic indicator of malignancy and a marker of cancer stem cells in solid tumors. The aim of this study was to correlate nestin levels with cytogenetic abnormalities in PC of MM patients. Our results indicate that high % Nes+PC or nestin levels significantly correlate with 1q21 gain, and low nestin levels correlate with HY. We suppose that nestin could associate with unfavorable prognosis but further studies are required to elucidate its clinical implication for MM
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