MicroRNAs and their target gene networks in renal cell carcinoma

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Authors

RÉDOVÁ Martina SVOBODA Marek SLABÝ Ondřej

Year of publication 2011
Type Article in Periodical
Magazine / Source Biochem Biophys Res Commun
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.sciencedirect.com/science/article/pii/S0006291X11000386
Doi http://dx.doi.org/10.1016/j.bbrc.2011.01.019
Field Oncology and hematology
Keywords MicroRNA; Renal cell carcinoma; Hypoxia; Epithelial-mesenchymal transition; Proliferation; Apoptosis
Description MiRNAs are related to the processes of cell proliferation, apoptosis, angiogenesis, invasion, and metastasis in RCC. MiRNAs expression profiles are associated with several RCC-specific genetic alterations. It has been well documented that several miRNAs are downstream effector molecules of the HIF-induced hypoxia response. MiR-200 family is linked to epithelial-mesenchymal transition which is one of the most significant pathogenetic mechanism in RCC. Mechanistic studies in RCC have provided the rationale of using miRNAs as potential therapeutic targets.
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