Project information
Bioaktivní látky ze sinic ovlivňující signálování jaderných receptorů a vývoj obratlovců
- Project Identification
- GA18-15199S
- Project Period
- 1/2018 - 12/2020
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
Our recent research showed that cyanobacteria contaminating fresh waters produce metabolites with endocrine disruptive potential, especially compounds with retinoid-like activity. The objective of this project is to gain important information on the biosynthesis, occurrence, developmental effects and mechanisms of action of the newly identified metabolites and prioritize compounds of the greatest significance for the specific toxic potential in the environment. The project will characterize effects of the prioritized compounds and their relevant mixtures on signaling of key nuclear receptors important for development (retinoic acid receptor, retinoid X receptor and thyroid receptor), on neuronal cells differentiation, as well as on early development and neurobehavior of Danio rerio embryos. An important goal is also to identify gene clusters or specific genes responsible for synthesis of retinoids in cyanobacteria and describe their biosynthetic pathways using modern bioinformatics tools. Project will bring crucial knowledge for risk assessment of environmental cyanobacterial water blooms.
Publications
Total number of publications: 11
2023
2022
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Teratogenicity of retinoids detected in surface waters in zebrafish embryos and its predictability by in vitro assays
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The Origin of Teratogenic Retinoids in Cyanobacteria
2021
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Cytotoxic and Genotoxic Effects of Cyanobacterial and Algal Extracts—Microcystin and Retinoic Acid Content
Toxins, year: 2021, volume: 13, edition: 2, DOI
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Highlighting the gaps in hazard and risk assessment of unregulated Endocrine Active Substances in surface waters: retinoids as a European case study
Environmental Sciences Europe, year: 2021, volume: 33, edition: 1, DOI
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Occurrence of cylindrospermopsin, anatoxin-a and their homologs in the southern Czech Republic-Taxonomical, analytical, and molecular approaches
Harmful Algae, year: 2021, volume: 108, edition: August 2021, DOI
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Variability in retinoid-like activity of extracellular compound mixtures produced by wide spectra of phytoplankton species and contributing metabolites
2020
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Current understanding of potential ecological risks of retinoic acids and their metabolites in aquatic environments
Environment International, year: 2020, volume: 136, edition: MAR 2020, DOI
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Field cyanobacterial blooms producing retinoid compounds cause teratogenicity in zebrafish embryos
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Neurobehavioral effects of cyanobacterial biomass field extracts on zebrafish embryos and potential role of retinoids