Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Cooperating Organization
-
Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 328
2020
-
DMD Pluripotent Stem Cell Derived Cardiac Cells Recapitulate in vitro Human Cardiac Pathophysiology
Frontiers in bioengineering and biotechnology, year: 2020, volume: 8, edition: June 2019, DOI
-
Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds
Cancers, year: 2020, volume: 12, edition: 6, DOI
-
Elimination of Viroids from Tobacco Pollen Involves a Decrease in Propagation Rate and an Increase of the Degradation Processes
International Journal of Molecular Sciences, year: 2020, volume: 21, edition: 8, DOI
-
Exkurze gymnázia Slovanské náměstí
Year: 2020, type: Popularization text
-
Functional Plasma Polymerized Surfaces for Biosensing
ACS Applied Materials & Interfaces, year: 2020, volume: 12, edition: 14, DOI
-
Functionalized Chiral Bambusurils: Synthesis and Host-Guest Interactions with Chiral Carboxylates
CHEMPLUSCHEM, year: 2020, volume: 85, edition: 6, DOI
-
HOW PHOSPHORYLATION IMPACTS 14-3-3ζ DIMERIZATION
Year: 2020, type: Conference abstract
-
Hymenobacter terrestris sp. nov. and Hymenobacter lapidiphilus sp. nov., isolated from regoliths in Antarctica
International Journal of Systematic and Evolutionary Microbiology, year: 2020, volume: 70, edition: 12, DOI
-
CHALLENGES IN STRUCTURAL AND INTERACTION PROPERTIES OF INTRINSICALLY DISORDERED PROTEINS
Year: 2020, type:
-
Characterization of Staphylococcus intermedius Group Isolates Associated with Animals from Antarctica and Emended Description of Staphylococcus delphini
Microorganisms, year: 2020, volume: 8, edition: 2, DOI