Driven hematopoietic differentiation of embryonic stem cells: Epigenetic perspectives

Logo poskytovatele

Varování

Publikace nespadá pod Filozofickou fakultu, ale pod Fakultu informatiky. Oficiální stránka publikace je na webu muni.cz.
Autoři

TESAŘOVÁ Lenka STEJSKAL Stanislav KRONTORÁD KOUTNÁ Irena

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj CURRENT PHARMACEUTICAL DESIGN
Fakulta / Pracoviště MU

Fakulta informatiky

Citace
Doi http://dx.doi.org/10.2174/13816128113199990524
Obor Genetika a molekulární biologie
Klíčová slova epigenetic; stem cells; pluripotency; cell differentiation; hematopoietic development
Popis Hematopoietic progenitors derived from human embryonic stem cells (hESCs) present both a potential cell source for cell-replacement therapies and an in vitro model for hematopoietic stem cell (HSC) development. Current protocols for the hematopoietic differentiation of hESCs suffer from low efficiency and functional defects in the derived HSCs. Epigenetic mechanisms of HSC development should be addressed to overcome these imperfections. The focus of this review is to summarize the knowledge on the epigenetic regulation of pluripotency and lineage-specific genes with the emphasis on the hematopoietic cell lineage. The potential utilization of this knowledge to improve the generation of HSCs for clinical application is also discussed.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.