Functional anatomy of outcome evaluation during Iowa Gambling Task performance in patients with Parkinson's disease: an fMRI study

Logo poskytovatele

Varování

Publikace nespadá pod Filozofickou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
Autoři

GESCHEIDT Tomáš MAREČEK Radek MIKL Michal CZEKÓOVÁ Kristína URBÁNEK Tomáš VANÍČEK Jiří SHAW Daniel Joel BAREŠ Martin

Rok publikování 2013
Druh Článek v odborném periodiku
Časopis / Zdroj NEUROLOGICAL SCIENCES
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://link.springer.com/content/pdf/10.1007%2Fs10072-013-1439-0.pdf
Doi http://dx.doi.org/10.1007/s10072-013-1439-0
Obor Neurologie, neurochirurgie, neurovědy
Klíčová slova Parkinsos's disease; Iowa Gambling Task; Decision-making; Dopamine; fMRI; Psychophysiological interactions
Popis The aim of this study was to investigate the functional anatomy of decision-making during the Iowa Gambling Task in patients with Parkinson's disease. We used event-related functional magnetic resonance imaging (fMRI) during a computerized version of IGT to compare 18 PD patients on dopaminergic medication in the ON state and 18 healthy control subjects. Our analyses focused on outcome evaluation following card selection, because we expected this aspect of decision-making to be impaired in PD patients. The PD patients exhibited lower activation of the left putamen than the control group as a reaction to penalty. Using psychophysiological interaction analysis, we identified decreased functional connectivity between the right globus pallidus internus and the left anterior cingulate gyrus in the PD group. In contrast, increased connectivity between these structures was observed after penalty in the control group. Our results suggest altered functioning of the basal ganglia and their connections with the cortical structures involved in the limbic loop (e.g., the limbic fronto-striatal circuit of the basal ganglia) during decision-making in PD patients. Differences in the response to loss could be associated with insufficient negative reinforcement after a loss in PD patients in the ON state in comparison to a healthy population.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.