Massive genomic variation and strong selection in Arabidopsis thaliana lines from Sweden

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Publikace nespadá pod Filozofickou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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LONG Quan RABANAL Fernando A. MENG Dazhe HUBER Christian D. FARLOW Ashley PLATZER Alexander ZHANG Qingrun VILHJÁLMSSON Bjarni J. KORTE Arthur NIZHYNSKA Viktoria VORONIN Viktor KORTE Pamela SEDMAN Laura MANDÁKOVÁ Terezie LYSÁK Martin SEREN Uemit HELLMANN Ines NORDBORG Magnus

Rok publikování 2013
Druh Článek v odborném periodiku
Časopis / Zdroj Nature Genetics
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://www.nature.com/ng/journal/v45/n8/full/ng.2678.html
Doi http://dx.doi.org/10.1038/ng.2678
Obor Genetika a molekulární biologie
Klíčová slova RIBOSOMAL-RNA GENES; LINKAGE DISEQUILIBRIUM; WIDE ASSOCIATION; NATURAL VARIATION; DNA; POPULATIONS; SEQUENCE; POLYMORPHISM; METHYLATION; ACCESSIONS
Popis Despite advances in sequencing, the goal of obtaining a comprehensive view of genetic variation in populations is still far from reached. We sequenced 180 lines of A. thaliana from Sweden to obtain as complete a picture as possible of variation in a single region. Whereas simple polymorphisms in the unique portion of the genome are readily identified, other polymorphisms are not. The massive variation in genome size identified by flow cytometry seems largely to be due to 45S rDNA copy number variation, with lines from northern Sweden having particularly large numbers of copies. Strong selection is evident in the form of long-range linkage disequilibrium (LD), as well as in LD between nearby compensatory mutations. Many footprints of selective sweeps were found in lines from northern Sweden, and a massive global sweep was shown to have involved a 700-kb transposition.
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