Effects of enrofloxacin, ciprofloxacin, and trimethoprim on two generations of Daphnia magna

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Publikace nespadá pod Filozofickou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
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BONA Mirco Dalla ZOUNKOVÁ Radka MERLANTI Roberta BLÁHA Luděk DE LIGUORO Marco

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj Ecotoxicology and Environmental Safety
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www http://www.sciencedirect.com/science/article/pii/S0147651314005302
Doi http://dx.doi.org/10.1016/j.ecoenv.2014.11.018
Obor Vliv životního prostředí na zdraví
Klíčová slova Daphnia magna; Fluoroquinolones; Trimethoprim; Transgenerational toxicity
Popis Multigenerational tests on Daphnia magna were performed exposing two subsequent generation to enrofloxacin (EFX) and its metabolite ciprofloxacin (CPX), and to trimethoprim (TMP). Mortality rate of 100% and 50% was detected in F0 at concentrations of >= 13 mg L-1 (EFX) and 50 mg L-1 (TMP), respectively. In F1 with respect to FO, both for growth and reproduction, a worsening trend of the response with EFX, a similar response with CPX and an attenuating trend with TMP was observed. Furthermore, the lowest EC20 for reproduction inhibition (1.3 mg L-1) was calculated for F1 exposed to EFX. However, other experimentations, longer and more complex, are necessary in order to confirm that EFX is more hazardous to daphnids than CPX and TMP. EC50 measured for the three assayed antibacterials were in the 6.5-37 mg L-1 range therefore environmental unrealistic, except in case of exceptional contaminations that may occur in relation to poorly controlled wastewaters from pharmaceutical factories or excessive use of prophylactic treatments in aquaculture.
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