Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathways

Publikace nespadá pod Filozofickou fakultu, ale pod Fakultu informatiky. Oficiální stránka publikace je na webu muni.cz.

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HAJNAL Matej ŠAFRÁNEK David DEMKO Martin PASTVA Samuel KREJČÍ Pavel BRIM Luboš

Rok publikování 2016
Druh Článek ve sborníku
Konference Hybrid Systems Biology. HSB 2016
Fakulta / Pracoviště MU

Fakulta informatiky

Citace
Doi http://dx.doi.org/10.1007/978-3-319-47151-8_4
Obor Informatika
Klíčová slova signalling pathways; systems biology; parameter synthesis; dynamical systems; parameter estimation
Popis Signalling pathways provide a complex cellular information processing machinery that evaluates particular input stimuli and transfers them into the genome by means of regulation of specific genes expression. In this short paper, we provide a preliminary study targeting minimal models representing the topology of main signalling mechanisms. A special emphasis is given to distinguishing between monotonous (sustained) and non-monotonous (transient) time-course behaviour. A set of minimal parametrised ODE models is formulated and analysed in a workflow based on formal methods.
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