Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study

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Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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LOŠÁK Jan HÜTTLOVÁ Jitka LIPOVÁ Petra MAREČEK Radek BAREŠ Martin FILIP Pavel ŽÚBOR Jozef USTOHAL Libor VANÍČEK Jiří KAŠPÁREK Tomáš

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Schizophrenia Bulletin
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1093/schbul/sbw065
Obor Psychiatrie, sexuologie
Klíčová slova predictive timing; cognitive dysmetria; schizophrenia; cerebellum; fMRI; dopamine
Přiložené soubory
Popis Abnormalities in both time processing and dopamine (DA) neurotransmission have been observed in schizophrenia. Time processing seems to be linked to DA neurotransmission. The cognitive dysmetria hypothesis postulates that psychosis might be a manifestation of the loss of coordination of mental processes due to impaired timing. The objective of the present study was to analyze timing abilities and their corresponding functional neuroanatomy in schizophrenia. We performed a functional magnetic resonance imaging (fMRI) study using a predictive motor timing paradigm in 28 schizophrenia patients and 27 matched healthy controls (HC). The schizophrenia patients showed accelerated time processing compared to HC; the amount of the acceleration positively correlated with the degree of positive psychotic symptoms and negatively correlated with antipsychotic dose. This dysfunctional predictive timing was associated with BOLD signal activity alterations in several brain networks, especially those previously described as timing networks (basal ganglia, cerebellum, SMA, and insula) and reward networks (hippocampus, amygdala, and NAcc). BOLD signal activity in the cerebellar vermis was negatively associated with accelerated time processing. Several lines of evidence suggest a direct link between DA transmission and the cerebellar vermis that could explain their relevance for the neurobiology of schizophrenia.
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