Analysis of Hemodynamic Related Changes in High Frequency Content of QRS Complex in Working Isolated Rabbit Heart

Logo poskytovatele

Varování

Publikace nespadá pod Filozofickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
Název česky Analýza hemodynamických změn ve vysokofrekvenční složce QRS komplexu u pracujícího izolovaného srdce králíka
Autoři

NOVOTNÁ Petra HEJČ Jakub RONZHINA Marina JANOUŠEK Oto STRAČINA Tibor OLEJNÍČKOVÁ Veronika NOVÁKOVÁ Marie KOLAROVA Jana

Rok publikování 2017
Druh Článek ve sborníku
Konference 2017 COMPUTING IN CARDIOLOGY (CINC)
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.22489/CinC.2017.293-442
Klíčová slova High Frequency Content of QRS Complex
Popis Aim: High frequency content of QRS complex (HF-QRS) is thought to be related to local conduction velocity (CV). There also exists the evidence suggesting the coupling between CV and mechanical stretch via so-called mechano-electric feedback. The aim of this study was to investigate possible relationship between left ventricular (LV) load and the most common HF-QRS parameters. Methods: Six isolated rabbit hearts in working mode underwent an experimental protocol consisting of upward and downward steps in preload (8-11 cmH(2)O). Eight unipolar pseudo-ECGs, left atrial pressure, and flow rate were recorded at f(s)=10 kHz and 16-bit resolution. QRS complexes from hemodynamically stable experiment phase were clustered, aligned, and decomposed into 3 HF-QRS bands followed by the assessment of power envelope RMS, the tallest peak value and its position. Results: No statistically significant changes associated with LV load alteration were observed in HF-QRS parameter. Conclusion: No evidence of load dependent changes in conduction velocity was found in the study. However, HF signal may represent a complex spatial depolarization behavior. Low sensitivity of used metrics should also be taken into consideration.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.