bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana

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PERNISOVÁ Markéta MOR Eliana MINNE Max CERUTTI Guillaume RIPPER Dagmar NOLF Jonah ANDRES Jennifer RAGNI Laura ZURBRIGGEN Matias D DE RYBEL Bert VERNOUX Teva

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj ISCIENCE
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://www.cell.com/iscience/fulltext/S2589-0042(22)01636-4
Doi http://dx.doi.org/10.1016/j.isci.2022.105364
Popis Root, shoot and lateral meristems are the main regions of cell proliferation in plants. It has been proposed that meristems might have evolved dedicated transcriptional networks to balance cell proliferation. Here, we show that basic Helix Loop Helix (bHLH) transcription factor heterodimers formed by members of the TARGET OF MONOPTEROS5 (TMO5) and LONESOME HIGHWAY (LHW) subclades are general regulators of cell proliferation in all meristems. Yet, genetics and expression analyses suggest specific functions of these transcription factors in distinct meristems, possibly due to their expression domains determining heterodimer complex variations within meristems, and to a certain extent to the absence of some of them in a given meristem. Target gene specificity analysis for heterodimer complexes focusing on the LONELY GUY gene targets further suggests differences in transcriptional responses through heterodimer diversification that could allow a common bHLH heterodimer complex module to contribute to cell proliferation control in multiple meristems.
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