Common xanthene fluorescent dyes are visible-light activatable CO-releasing molecules

Varování

Publikace nespadá pod Filozofickou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	MARTÍNEK Marek LUDVÍKOVÁ Lucie ŠRANKOVÁ Mária NAVRÁTIL Rafael MUCHOVÁ Lucie HUZLÍK Jiří VÍTEK Libor KLÁN Petr ŠEBEJ Peter
Rok publikování	2023
Druh	Článek v odborném periodiku
Časopis / Zdroj	Organic and Biomolecular Chemistry
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
www	https://pubs.rsc.org/en/content/articlelanding/2023/OB/D2OB01823C
Doi	http://dx.doi.org/10.1039/d2ob01823c
Klíčová slova	CARBON-MONOXIDE; QUANTUM YIELD; EOSIN-Y; PHOTOCHEMISTRY; OXYGEN; PHOTODEGRADATION; ANGIOGRAPHY; MECHANISM
Popis	Fluorescein, eosin Y, and rose bengal are dyes used in clinical medicine and considered (photo-)chemically stable. Upon extensive irradiation with visible light in aqueous solutions, we found that these compounds release carbon monoxide (CO) - a bioactive gasotransmitter - in 40-100% yields along with the production of low-mass secondary photoproducts, such as phthalic and formic acids, in a multistep degradation process. Such photochemistry should be considered in applications of these dyes, and they could also be utilized as visible-light activatable CO-releasing molecules (photoCORMs) with biological implications.
Související projekty:	CETOCOEN Excellence CETOCOEN Excellence Nové strukturní motivy pro rozšíření možností lineárních polymethinových barviv RECETOX RI